Table 1.

PFC Subregional Contribution to Drug-seeking Behavior

Sub-region	Drug	CS/Extinction	Context/Extinction	Abstinence	Drug Priming	Stress
ACC/PL	Cocaine	Arc ↑, Fos ↑		Fos ↑, Arc ↑, RGS4 ↑, DAT ↑
		TTX ↓	TTX ↓	BM –	BM ↓, TTX ↓, DA antagonists ↓–, PL lesion ↓	BM ↓, TTX ↓, D1 antagonist ↓, D2 antagonist –
	Methamphetamine	lidocaine ↓, nACh agonist ↓			lidocaine ↓, nACh agonist ↓
	Heroin	ania-3 ↑, MKP-1 ↑, zif268 ↑, c-fos ↑, Nr4a3 ↑				Fos ↑
		B/M ↓↑			B/M ↓
	Ethanol		Fos ↑
IL	Cocaine		Fos ↑	Fos ↑, pERK ↑
		TTX –	TTX –	B/M ↓	TTX –, BM –	TTX –, BM –
	Methamphetamine	lidocaine –			lidocaine –
	Heroin	AMPA GluR2 ↓
		BM ↓, CB1 antagonist ↓			BM ↓
OFC	Cocaine	Arc ↑		Fos ↑
		lesion –, lOFC: BM ↓ mOFC: BM –	lOFC: BM ↓, lesion ↑ mOFC: BM –		BM –, TTX –, lOFC: lesion ↑ mOFC: lesion ↓	TTX ↓, D1 antagonist ↓, D2 antagonist –
	Heroin	ania-3 ↑

↑ denotes an increase, ↓ denotes a decease, and – denotes no observed change, in gene or protein expression or in drug-seeking behavior. Abbreviations: anterior cingulate cortex (ACC), baclofen plus muscimol (BM), canabinoid 1 (CB1), dopamine transporter protein (DAT), dopamine 1 (D1), dopamine 2 (D2), infralimbic cortex (IL), lateral orbitofrontal cortex (lOFC), medial orbitofrontal cortex (mOFC), nicotinic cholinergic (nACh), phospho-extracellular-related kinase (p-ERK), prelimbic cortex (PL), regulator of G-protein signaling 4 (RGS4), tetrodotoxin (TTX).