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. 2015 Mar 27;7:57–68. doi: 10.2147/CPAA.S79760

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© Chakrabarti et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Agents targeting specific NADPH-biogenesis pathways.

Abbreviations: NADPH, nicotinamide adenine dinucleotide phosphate; BPTES, bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3; PPP, pentose phosphate pathway; PKM2, pyruvate kinase 2; ME, malic enzyme; GLS1, glutaminase 1; NAMPT, nicotinamide phosphoribosyltransferase; TS, thymidylate synthase; DHFR, dihydrofolate reductase; TIGAR, TP53-induced glycolysis and apoptosis regulator; PDAC, pancreatic ductal adenocarcinomas; SHMT2, serine hydroxymethyltransferase 2; MTHFD2, methylenetetrahydrofolate dehydrogenase 2.