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NADPH biogenesis via IDH1.
Note: Cytoplasmic NADPH generated by IDH1 and mitochondrial NADPH generated by IDH2.
Abbreviations: IDH1, isocitrate dehydrogenase 1; NADPH, nicotinamide adenine dinucleotide phosphate; IDH2, isocitrate dehydrogenase 2; αKG, α-ketoglutarate.
