Table 2.
Leeds Psychomotor Test Battery (critical flicker fusion threshold; motor reaction time; recognition reaction time; total reaction time) and car-driving simulation (total time score; best lap time) results before and after a single oral dose of mexazolam 1 mg or placebo in healthy volunteers
| Placebo | Mexazolam | |||
|---|---|---|---|---|
| Pre-dose | Post-dose | Pre-dose | Post-dose | |
| Leeds Psychomotor Test Battery results | ||||
| CFF threshold (Hz) | 29.03 ± 2.94 | 29.06 ± 3.01 | 29.62 ± 3.01 | 28.85 ± 3.35 |
| RRT (ms) | 379.74 ± 44.29 | 385.87 ± 39.59 | 381.18 ± 56.64 | 378.42 ± 36.66 |
| MRT (ms) | 209.25 ± 39.92 | 208.77 ± 43.90 | 210.35 ± 37.24 | 205.05 ± 33.58 |
| TRT (ms) | 588.99 ± 67.00 | 594.64 ± 63.22 | 591.52 ± 74.58 | 583.47 ± 51.37 |
| Car-driving simulation results | ||||
| TTS (s) | 745.69 ± 208.70 | 708.61 ± 125.45* | 724.70 ± 90.73 | 707.19 ± 75.15* |
| BLT (s) | 44.73 ± 9.81 | 43.02 ± 6.07* | 43.69 ± 4.12 | 43.02 ± 3.19* |
Data shown are mean ± SD. Data from Silveira et al. [18]
BLT best lap time, CFF critical flicker fusion, Hz Hertz, MRT motor reaction time, ms millisecond, RRT recognition reaction time; s second, TRT total reaction time
* P < 0.05 versus pre-dose values