Fig. 1.

Effects of acute and chronic tandospirone (TDS) treatment on the time to feeding (latency) in a Novelty Suppressed Feeding (NSF) test. The results are expressed as the cumulative survival of animals that have not eaten for over 12 min (left panel) or as the mean latency to feeding in seconds (right panel). The administration of TDS (10 mg/kg) 20 min prior to testing resulted in a significant reduction in the latency to feeding compared with a vehicle-treated group (a, b). However, no significant differences in the NSF test were observed between the vehicle- and TDS-treated groups 24 h after 14 days of TDS treatment (c, d). *P < 0.05, **P < 0.01 vs. vehicle-treated group; ^# P < 0.05 vs. TDS 1 mg/kg-treated group (Kaplan–Meier survival analysis, Mantel–Cox log-rank test or one-way ANOVA followed by Bonferroni/Dunn post hoc analysis)