. Author manuscript; available in PMC: 2016 Jan 31.

Published in final edited form as: J Heart Lung Transplant. 2014 Oct 2;34(2):227–232. doi: 10.1016/j.healun.2014.09.036

Table 3.

Risk Factors for Invasive Fungal Disease

	Univariable HR (95% CI), p-value	Multivariable HR (95% CI), p-value
Age, per decade	1.04 (0.74–1.47), 0.83	—
Male gender	0.75 (0.31–1.84), 0.51	—
Pre-transplant VAD	0.87 (0.27–2.84), 0.82	—
CMV disease	1.39 (0.19–10.3), 0.75	—
Additional induction immunosuppression	2.95 (1.28–6.77), 0.01	2.68 (1.16–6.20), 0.02
Reoperation within 10 days	2.33 (1.02–5.33), 0.05	—
Delayed chest closure	3.54 (1.53–8.20), 0.003	3.26 (1.40–7.60), 0.006
Peri-transplant VAD placement	10.0 (3.27–30.5), <0.001	—

CI, confidence interval; CMV, cytomegalovirus; HR, hazard ratio; HT, heart transplant; IFD, invasive fungal disease; VAD, ventricular assist device.

A time-dependent Cox model for acute cellular rejection failed to converge—there were no IFD events 90 to 180 days after treatment for acute cellular rejection in the study cohort. Reoperation within 10 days of HT, peri-operative VAD placement and delayed chest closure were collinear variables, so we included only delayed chest closure in the multivariable model.