Figure 1. Immunohistochemical localization of NR1I3 in lung tumors of mice treated with 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone (NNK). A and B: Representative solid-type lung adenomas with intense staining for NR1I3 in cytoplasm and most nuclei. C: Solid-type lung adenocarcinoma with bronchiolar invasion. D: Higher magnification of invasive component. Note NR1I3 expression mostly in cytoplasm, and in nuclei of a few cells. E, Papillary lung adenocarcinoma. F, Higher magnification of malignant lesion showing few positive nuclei staining. Red bar: 250 μm; black bar: 25 μm.
