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Regulation of TACI expression. Activation TLR4, TLR7, or TLR9 increases TACI expression in B cells. Ligation of CD40 or BCR activation also results in elevated TACI expression in B cells (1). However, IL-21 downregulates TACI expression in GC B cells (2). TACI expression in B cells increases with age before adulthood (3).
