Table 1: Characteristics of included studies.

Study	Sex	Mean age, yr	No. of participants*	Type of intervention for prior weight loss	Intervention type	Control	Intervention length, mo.	Location	Publication date
Champagne et al.17 Svetkey et al.18	M + F	55	1032	Six-month diet plus group-based support	Lifestyle (delivery strategies: Internet or personal contact)	Self-directed	30	US	2011
Davidson et al.12	M + F	43	306	120 mg orlistat 3×/d for 1 yr plus controlled-energy diet	120 mg orlistat 3×/d plus weight-maintenance diet	Placebo plus same weight-maintenance diet	12	US	1999
Hauptman et al.13	M + F	42	273	120 mg orlistat 3×/d for 1 yr plus energy-reduced diet	120 mg orlistat 3×/d plus weight-maintenance diet	Placebo plus same weight-maintenance diet	12	US	2000
Hill et al.14	M + F	46	369	Six-month hypoenergetic diet plus encouraged to exercise	120 mg orlistat 3×/d plus dietary and behavioural counselling	Placebo plus same diet and behavioural components	12	US	1999
Richelsen et al.15	M + F	47	309	Eight-week very low-energy diet	120 mg orlistat 3×/d plus energy-restricted diet and dietary and lifestyle counselling	Placebo plus same diet and behavioural components	36	Scandinavia	2007
Rickel et al.19 Perri et al.20 Radcliff et al.21	F	59	234	Six-month group-based lifestyle program	Six-month group-based lifestyle program	Newsletters with tips and recipes	6	US	2011
Sjöström et al.16	M + F	45	261	120 mg orlistat 3×/d for 1 yr plus hypocaloric diet	120 mg orlistat 3×/d plus weight-maintenance diet	Placebo plus weight-maintenance diet	12	Europe	1998
Thomas et al.22	Not reported	45	55	Not reported (recruited from a weight loss clinic)	Weekly emails from a dietician with dietary, behavioural and exercise advice	No contact	6	UK	2011

Note: F = female, M = male.
*If a study included multiple treatment arms with different doses of orlistat, only the 120 mg group was included.