Table 2: Trend analysis of end-stage renal disease over time, by sex and health region.

Variable	Incidence				Prevalence
	No. of inflection points	Period	Annual percentage change* (95% CI)		No. of inflection points	Period	Annual percentage change* (95% CI)
Sex
Female	1	1989–1998	7.3	(3.7 to 11.1)*	2	1989–1991	87.5	(53.1 to 129.6)*
		1998–2010	1.3	(–0.4 to 3.1)		1991–1999	14.2	(12.8 to 15.5)*
						1999–2010	4.2	(3.8 to 4.6)*
Male	0	1989–2010	3.2	(2.5 to 3.9)*	2	1989–1992	45.8	(36.6 to 55.5)*
						1992–1998	12.2	(10.5 to 13.9)*
						1998–2010	4.5	(4.2 to 4.8)*
Health region
Mid rural	0	1989–2010	2.6	(1.5 to 3.6)*	2	1989–1991	69.6	(31.7 to 118.4)*
						1991–1998	13.2	(10.8 to 15.7)*
						1998–2010	4.0	(3.4 to 4.5)*
North rural	0	1989–2010	5.5	(4.4 to 6.5)*	2	1989–1993	45.0	(31.1 to 60.4)*
						1993–2001	9.0	(6.8 to 11.4)*
						2001–2010	5.1	(4.1 to 6.1)*
South rural	0	1989–2010	3.4	(2.3 to 4.6)*	2	1989–1992	53.1	(31.9 to 77.7)*
						1992–1998	13.6	(9.9 to 17.4)*
						1998–2010	4.0	(3.4 to 4.7)*
Urban	0	1989–2010	3.0	(2.2 to 3.9)*	2	1989–1992	48.1	(34.3 to 63.3)*
						1992–1999	12.0	(10.2 to 13.9)*
						1999–2010	4.4	(3.9 to 4.9)*

Note: CI = confidence interval.
*Significantly different from zero at α = 0.001.