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. 2015 Apr 1;10(4):e0122410. doi: 10.1371/journal.pone.0122410

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© 2015 Andreou et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 3 — A. Representative example of thrombin generation in normal human plasma initiated with 4 pM TF measured in the presence of 2.5 nM wt APC or non-anticoagulant APC variants. B-C. Inhibition of TF-induced thrombin generation with increasing concentrations of either human (B) or murine (C) APC variants. The ETP in the absence of APC was taken as 100% and the ETP generated in the presence of each human (0 to 50 nM) or murine (0 to 20 nM) APC variant was expressed as a percentage of this. Values (n = 4) represent the mean±SD.