Table 1. Catalytic efficiencies (kcat/Km) of human (h) and murine (m) APC and variant APC-mediated proteolysis of the peptide substrate, S2366.
APC | kcat/Km (μM-1s-1) |
---|---|
hWT | 0.22 ±0.02 |
hAPC(5A) | 0.20 ±0.01 |
hAPC(36–39) | 0.22 ±0.01 |
hAPC(Ca-ins) | 0.17 ±0.02 |
mWT | 0.22 ±0.03 |
mAPC(5A) | 0.21 ±0.01 |
mAPC(36–39) | 0.23 ±0.01 |
mAPC(Ca-ins) | 0.17 ±0.02 |