Table 2. Properties of HIV-1 strains lacking Vpu or encoding mutations that underlie resistance to ARVs.
HIV-1 strain | Protein | Primary mutation(s) | Resistance to ARVs tested |
---|---|---|---|
Δvpu | vpu | vpu open reading frame deleted | n/a |
PR+RT | protease | M46L, I54V, I84V, L90M | IND + EFV |
reverse transcriptase | K101E, Y181C, G190A | ||
RT | reverse transcriptase | K103N, V108I, M230L | EFV |
INT | integrase | N155H | RAL |