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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Exp Neurol. 2014 Dec 24;265:8–21. doi: 10.1016/j.expneurol.2014.12.015

Fig. 10.

Fig. 10

Repetitive i.th. application of anti-AQP4 AB leads to functional consequences in nerve fiber transmission in evoked potential recording and to reduction of NMDA receptor NR1 expression at lesion sites. A: In electrophysiological SSEP recordings, peak N1 amplitudes were reduced after i.th. application of NMO IgG derived from two individual NMO patients (color-coded) but not after i.th. applied control IgG. In contrast, SSEP latencies to the first positive (P1) and negative deflections (N1) were unchanged compared to baseline values *p < 0.05, group comparison). Representative recordings are shown from one of total 28 rats with measurements taken ipsilateral to the side of IgG application, before and after completion of i.th. NMO-IgG applications on day 25. B: The expression of NMDA receptor NR1 subunit was reduced ipsilateral to the catheter ending in comparison to the contralateral side. The amount of NR1 immunoreactive spots and the signal density of NR1-positive structures were diminished after i.th. application of NMO-IgG (middle column) and similarly so with rABAQP4 (right column; scale bar: 50 μm) (for interpretation of the references to color in this figure legend, the reader is referred to the web version of the article).