Table 1.
Novel GWS BMI loci In European meta-analysis
| SNP | Chr:position | Notable gene(s)* | Alleles | EAF | β | s.e.m. | P value |
|---|---|---|---|---|---|---|---|
| rs657452 | 1:49,362,434 | AGBL4(N) | A/G | 0.394 | 0.023 | 0.003 | 5.48 × 10−13 |
| rs12286929 | 11:114,527,614 | CADM1(N) | G/A | 0.523 | 0.022 | 0.003 | 1.31 × 10−12 |
| rs7903146 | 10:114,748,339 | TCF7L2(B,N) | C/T | 0.713 | 0.023 | 0.003 | 1.11 × 10−11 |
| rs10132280 | 14:24,998,019 | STXBP6(N) | C/A | 0.682 | 0.023 | 0.003 | 1.14 × 10−11 |
| rs17094222 | 10:102,385,430 | HIF1AN(N) | C/T | 0.211 | 0.025 | 0.004 | 5.94 × 10−11 |
| rs7599312 | 2:213,121,476 | ERBB4(D,N) | G/A | 0.724 | 0.022 | 0.003 | 1.17 × 10−10 |
| rs2365389 | 3:61,211,502 | FHIT(N) | C/T | 0.582 | 0.020 | 0.003 | 1.63 × 10−10 |
| rs2820292 | 1:200,050,910 | NAV1(N) | C/A | 0.555 | 0.020 | 0.003 | 1.83 × 10−10 |
| rs12885454 | 14:28,806,589 | PRKD1(N) | C/A | 0.642 | 0.021 | 0.003 | 1.94 × 10−10 |
| rs16851483 | 3:142,758,126 | RASA2(N) | T/G | 0.066 | 0.048 | 0.008 | 3.55 × 10−10 |
| rs1167827 | 7:75,001,105 |
HIP1(B,N); PMS2L3(B,Q); PMS2P5(Q); WBSCR16(Q) |
G/A | 0.553 | 0.020 | 0.003 | 6.33 × 10−10 |
| rs758747 | 16:3,567,359 | NLRC3(N) | T/C | 0.265 | 0.023 | 0.004 | 7.47 × 10−10 |
| rs1928295 | 9:119,418,304 | TLR4(B,N) | T/C | 0.548 | 0.019 | 0.003 | 7.91 × 10−10 |
| rs9925964 | 16:31,037,396 |
KAT8(N);ZNF646(M,Q); VKORC1(Q); ZNF668(Q); STX1B(D); FBXL19(D) |
A/G | 0.620 | 0.019 | 0.003 | 8.11 × 10−10 |
| rs11126666 | 2:26,782,315 | KCNK3(D,N) | A/G | 0.283 | 0.021 | 0.003 | 1.33 × 10−9 |
| rs2650492 | 16:28,240,912 | SBK1(D,N); APOBR(B) | A/G | 0.303 | 0.021 | 0.004 | 1.92 × 10−9 |
| rs6804842 | 3:25,081,441 | RARB(B) | G/A | 0.575 | 0.019 | 0.003 | 2.48 × 10−9 |
| rs4740619 | 9:15,624,326 | C9orf93(C,M,N) | T/C | 0.542 | 0.018 | 0.003 | 4.56 × 10−9 |
| rs13191362 | 6:162,953,340 | PARK2(B,D,N) | A/G | 0.879 | 0.028 | 0.005 | 7.34 × 10−9 |
| rs3736485 | 15:49,535,902 | SCG3(B,D); DMXL2(M,N) | A/G | 0.454 | 0.018 | 0.003 | 7.41 × 10−9 |
| rs17001654 | 4:77,348,592 | NUP54(M); SCARB2(Q,N) | G/C | 0.153 | 0.031 | 0.005 | 7.76 × 10−9 |
| rs11191560 | 10:104,859,028 | NT5C2(N); CYP17A1(B); SFXN2(Q) | C/T | 0.089 | 0.031 | 0.005 | 8.45 × 10−9 |
| rs1528435 | 2:181,259,207 | UBE2E3(N) | T/C | 0.631 | 0.018 | 0.003 | 1.20 × 10−8 |
| rs1000940 | 17:5,223,976 | RABEP1(N) | G/A | 0.320 | 0.019 | 0.003 | 1.28 × 10−8 |
| rs2033529 | 6:40,456,631 | TDRG1(N); LRFN2(D) | G/A | 0.293 | 0.019 | 0.003 | 1.39 × 10−8 |
| rs11583200 | 1:50,332,407 | ELAVL4(B,D,N,Q) | C/T | 0.396 | 0.018 | 0.003 | 1.48 × 10−8 |
| rs9400239 | 6:109,084,356 | FOXO3(B,N); HSS00296402(Q) | C/T | 0.688 | 0.019 | 0.003 | 1.61 × 10−8 |
| rs10733682 | 9:128,500,735 | LMX1B(B,N) | A/G | 0.478 | 0.017 | 0.003 | 1.83 × 10−8 |
| rs11688816 | 2:62,906,552 | EHBP1(B,N) | G/A | 0.525 | 0.017 | 0.003 | 1.89 × 10−8 |
| rs11057405 | 12:121,347,850 | CLIP1(N) | G/A | 0.901 | 0.031 | 0.006 | 2.02 × 10−8 |
| rs11727676 | 4:145,878,514 | HHIP(B,N) | T/C | 0.910 | 0.036 | 0.006 | 2.55 × 10−8 |
| rs3849570 | 3:81,874,802 | GBE1(B,M,N) | A/C | 0.359 | 0.019 | 0.003 | 2.60 × 10−8 |
| rs6477694 | 9:110,972,163 | EPB41L4B(N); C9orf4(D) | C/T | 0.365 | 0.017 | 0.003 | 2.67 × 10−8 |
| rs7899106 | 10:87,400,884 | GRID1(B,N) | G/A | 0.052 | 0.040 | 0.007 | 2.96 × 10−8 |
| rs2176598 | 11:43,820,854 | HSD17B12(B,M,N) | T/C | 0.251 | 0.020 | 0.004 | 2.97 × 10−8 |
| rs2245368 | 7:76,446,079 | PMS2L11(N) | C/T | 0.180 | 0.032 | 0.006 | 3.19 × 10−8 |
| rs17724992 | 19:18,315,825 | GDF15(B); PGPEP1(Q,N) | A/G | 0.746 | 0.019 | 0.004 | 3.42 × 10−8 |
| rs7243357 | 18:55,034,299 | GRP(B,G,N) | T/G | 0.812 | 0.022 | 0.004 | 3.86 × 10−8 |
| rs2033732 | 8:85,242,264 | RALYL(D,N) | C/T | 0.747 | 0.019 | 0.004 | 4.89 × 10−8 |
GWS isdefinedas P < 5 × 10−8. SNP positions are reported according to Build 36 and their alleles are coded based on the positive strand. Alleles (effect/other), effect allele frequency (EAF), beta (β), standard error of the mean (s.e.m.) and P values are based on the meta-analysis of GWAS I + II + Metabochip association data from the European sex-combined data set.
*
Notable genes from biological relevance to obesity (B); copy number variation (C); DEPICT analyses (D); GRAIL results (G); BMI-associated variantis in strong LD (r2 ≥ 0.7) with a missens evariant in the indicated gene (M); gene nearest to index SNP (N); association and eQTL data converge to affect gene expression (Q).