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. 2014 Dec 15;125(1):437–447. doi: 10.1172/JCI78794

Figure 9. I538V/Q546L/T563V mutations in E2 confer resistance to neutralization by plasma from HCV-infected subjects.

Figure 9

Introduction of I538V/Q546L/T563V into sensitive E1E2 clone 1b09 or back mutation of V538 to I, L546 to Q, and V563 to T in resistant clone 1a129 confers increased resistance or sensitivity, respectively, to neutralization by plasma samples from 18 HCV-infected subjects. Each box represents relative infection of the indicated HCVpp in the presence of each of 18 plasma samples. Dots indicate neutralization by plasma from the source donor of resistant E1E2 clone 1a129. Plasma was tested for neutralizing activity at a 1:100 dilution. Black bars indicate medians. Whiskers indicate 10th and 90th percentiles. P values were calculated by Wilcoxon signed-rank test.