Fig 4. Cognitive function in monocyte-infused APPSwDI mice.
Spatial learning and memory were assessed using a modified win-shift procedure in an 8-arm maze (A) every two weeks. Intravenous infusions of 5 x 106 young monocytes (pM, filled circle; n = 8) or saline (unfilled diamond; n = 7) took place at 0, 4, and 8 weeks. To test memory function, animals were evaluated for total number of visits (B) to radial arms, and working memory errors (C) measured over two sessions. Anxiety was tested using a black/white box (A) over 5 sessions and quantified by the number of seconds it took the animal to leave the white area (D). Plotted data represents the mean ± SEM performance of each animal group (n = 5). Statistical analysis was performed using a Student’s t-test (* p < 0.05, ** p < 0.01).