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. 2015 Apr;135(4):998–1007.e6. doi: 10.1016/j.jaci.2014.08.030

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© 2014 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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Fig E2 — Evidence for a defect in cell survival and sensitivity to DNA-damaging agents in CH12-F3 INO80-knockdown cells. Immunoblot analysis of INO80 and GAPDH in whole-cell extracts of CH12-F3 cells expressing indicated shRNA (A). Analysis of apoptosis; geometric mean for annexin V staining is indicated (B). Dead cells were excluded by topro-3 incorporation. Counter selection of CH12-F3 cells expressing INO80-specific shRNA (C). Proliferation profile of CH12-F3 cells expressing INO80-specific or control shRNAs (D). Increased sensitivity to γ-radiation, UV radiation, and mitomycin C (MMC) treatment in CH12-F3 cells expressing INO80-specific shRNA (sh INO-7), compared with a nonspecific, control shRNA (sh scramble) (E).