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. 2015 Apr;135(4):998–1007.e6. doi: 10.1016/j.jaci.2014.08.030

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© 2014 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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Fig 3 — Early separation of sister chromatids in CH12-F3 INO80 knockdown cells. Chromosomal aberrations in metaphase spreads hybridized with a telomere probe and counterstained with DAPI from activated CH12-F3 cells expressing INO80-specific shRNA (sh INO-7; black bar) or a nonspecific control shRNA (sh scramble; white bar) (A); 39 to 62 metaphases were analyzed. P values from unpaired Student t test are quoted; ns, not significant. A representative metaphase spread with early separation of sister chromatids (indicated by an arrow), from nonstimulated CH12-F3 cells expressing INO80-specific shRNA (B). Frequency of metaphases with abnormal separation of sister chromatids in nonstimulated CH12-F3 cells expressing INO80-specific shRNAs (sh INO-6 and sh INO-7; grey and black bars, respectively) or a nonspecific control shRNA (sh scramble; white bar) (C). In 2 independent experiments, 41 to 49 metaphases were analyzed (mean and SEM). The P value from an unpaired Student t test is quoted.