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. Author manuscript; available in PMC: 2015 Apr 2.
Published in final edited form as: Cell Rep. 2015 Mar 26;10(12):1967–1973. doi: 10.1016/j.celrep.2015.02.061

Figure 4. Front-head gating model for kinesin.

Figure 4

(1) In the ATP waiting state, the rear head is ADP-bound and weakly interacting with MT. (2) ATP binding to the front head triggers NL docking that pulls the rear head forward. (3) The unbound head releases ADP and rebinds MT ahead of its partner head. (3–4) In 2HB state, the NL of the front head (red) is oriented backward and ATP binding to this head is inhibited until the rear head hydrolyzes ATP and releases from MT.