Table 1.
Systemic characteristics and cardiac Function in the 4 groups (mean±SEM, n=7 each).
| Sham | HT | CAS | CAS+HT | P Value for Two-way ANOVA | |||
|---|---|---|---|---|---|---|---|
|
| |||||||
| HT | CAS | HT×CAS | |||||
| Body weight, kg | 48.0±2.8 | 48.3±5.2 | 51.6±4.6 | 46.1±5.0 | |||
| MAP, mmHg | 96.7±2.8 | 116.5±7.8* | 101.3±5.6 | 112.5±7.0* | 0.028 | 0.961 | 0.519 |
| PRA, pg·ml-1·h-1 | 0.17±0.10 | 0.25±0.16 | 0.22±0.07 | 0.24±0.15 | 0.505 | 0.786 | 0.648 |
| Creatinine, mg·dL-1 | 1.17±0.31 | 1.58±0.17* | 1.62±0.32* | 1.80±0.16* | 0.016 | 0.008 | 0.326 |
| Urine Protein,μg·ml-1 | 16.9±2.5 | 22.1±5.9 | 18.4±6.1 | 33.4±4.7*& | 0.047 | 0.199 | 0.319 |
| Norepinephrine,ng·ml-1 | 0.08±0.02 | 0.10±0.02 | 0.04±0.01# | 0.05±0.01 | 0.290 | 0.01 | 0.583 |
| Degree of CAS, % | 0 | 0 | 77.3±8.9*# | 74.0±10.3*# | |||
| Stoke volume, ml | 48±2 | 50±3 | 48±5 | 37±3*# | 0.262 | 0.045 | 0.078 |
| Ejection fraction, % | 50±3 | 57±4 | 45±5 | 45±3 | 0.421 | 0.046 | 0.426 |
| E/A | 1.07±0.06 | 1.02±0.15 | 1.20±0.15 | 1.14±0.12 | 0.652 | 0.313 | 0.946 |
HT, hypertension; CAS, coronary artery stenosis; MAP, mean arterial pressure; PRA, plasma renin activity; E/A, early-to-late left ventricular filling velocities.
*
P<0.05 vs. Sham;
#
P<0.05 vs. HT;
&
P<0.05 vs. CAS.