Table 2.
Non-stenotic kidney hemodynamics and function in Sham, coronary artery stenosis (CAS), hypertension (HT) and CAS+HT pigs (mean±SEM, n=7 each).
| Sham | HT | CAS | CAS+HT | P Value for Two-way ANOVA | |||
|---|---|---|---|---|---|---|---|
|
| |||||||
| HT | CAS | HT×CAS | |||||
| Degree of renal artery stenosis, % | 0 | 81.7±7.5*& | 0 | 80.7±5.7*& | |||
| RBF, ml·min-1 | |||||||
| Basal | 469.0±63.1 | 779.4±81.1* | 422.3±82.5# | 428.5±51.0# | 0.031 | 0.008 | 0.037 |
| Ach | 677.4±32.5† | 969.4±83.3*† | 590.6±111.0#† | 482.0±48.5*# | 0.192 | 0.0003 | 0.007 |
| Perfusion, ml·min-1·ml-1 | |||||||
| Cortex: baseline | 4.10±0.47 | 5.03±0.75 | 3.80±0.46# | 4.03±0.30# | 0.141 | 0.103 | 0.371 |
| Ach | 6.21±0.29† | 6.30±0.59† | 4.94±0.60*#† | 5.12±0.40*#† | 0.781 | 0.017 | 0.920 |
| Medulla: baseline | 2.84±0.44 | 2.19±0.10 | 1.98±0.35 | 2.00±0.35 | 0.370 | 0.146 | 0.342 |
| Ach | 3.77±0.55† | 3.47±0.43† | 3.82±0.47† | 2.48±0.39*& | 0.095 | 0.328 | 0.281 |
| RVR, mmHg·min-1·ml-1 | 0.18±0.02 | 0.16±0.02 | 0.27±0.04*# | 0.29±0.04*# | 0.511 | 0.012 | 0.174 |
RBF, renal blood flow; Ach, acetylcholine; ITC, intratubular concentration; RVR, renal vascular resistance.
*
P<0.05 vs. Sham;
#
P<0.05 vs. HT;
&
P<0.05 vs. CAS.
†
P<0.05 vs. baseline.