Skip to main content
. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Nat Methods. 2015 Feb 23;12(4):366–372. doi: 10.1038/nmeth.3296

Figure 4.

Figure 4

Prediction of the ion distributions of m/z 646.4 and 788.5 in mouse brain at 330 nm resolution from 10 μm IMS and 330 nm microscopy measurements (sharpening). Measured ion images acquired in mouse brain for m/z 646.4 and m/z 788.5 at 10 μm spatial resolution (a) are fused with an H&E-stained microscopy image measured at 0.33 μm resolution (b). The resulting IMS-microscopy model is combined with the microscopy measurements to predict the ion distributions of m/z 646.4 and m/z 788.5 at 330 nm resolution with an overall reconstruction score of respectively 75% and 76% (c).