Table 4.

Adjusted Hazard Ratios (95% Confidence Intervals) for Incident ESRD by Serum Magnesium Levels

Serum magnesium	Quartile 1a	Quartile 1b	Quartile 2	Quartiles 3 and 4	P-trend
mmol/L	0.25–0.70	0.75	0.80	0.85–1.15
Model 1	4.58 (3.14, 6.69)	2.10 (1.40, 3.16)	1.44 (0.97, 2.14)	1.00	<0.001
Model 2	2.66 (1.80, 3.93)	1.66 (1.10, 2.49)	1.30 (0.88, 1.93)	1.00	<0.001
Model 3	2.39 (1.61, 3.56)	1.50 (0.99, 2.27)	1.26 (0.84, 1.87)	1.00	<0.001

Model 1: controlling for race-center, age, and gender

Model 2: Model 1 + baseline eGFR, diabetes, and hypertension medication status

Model 3: Model 2 + education levels, household income, health insurance status, systolic blood pressure, prevalent coronary heart disease, smoking status, log-transformed triglycerides, HDL-C, log-transformed LDL-C, and serum albumin.

Quartiles 3 and 4 were combined for analysis because in African American, only four ESRD events were observed in quartile 4.

P-values for trend were obtained by coding serum magnesium levels as a continuous variable from 0 to 3.