Table 5.
Significantly activated and inhibited upstream regulators
| Upstream Regulator | Predicted Activation State | Activation z-score | p-value |
|---|---|---|---|
| IFNG | Activated | 2.940 | 0.000005 |
| IL6 | Activated | 2.862 | 0.0000004 |
| IFN alpha/beta | Activated | 2.828 | 0.021 |
| NFkB (complex) | Activated | 2.501 | 0.005 |
| IL27 | Activated | 2.327 | 0.031 |
| SNAI2 | Activated | 2.236 | 0.0326 |
| EBI3 | Activated | 2.186 | 0.0357 |
| CTCF | Activated | 2.000 | 0.0124 |
| NPPB | Activated | 2.000 | 0.0377 |
| Creb | Inhibited | −2.000 | 0.009 |
| mir-21 | Inhibited | −2.043 | 0.011 |
| RXRA | Inhibited | −2.046 | 0.019 |
| ESR2 | Inhibited | −2.060 | 0.001 |
| NR1I3 | Inhibited | −2.064 | 0.004 |
| FGFR2 | Inhibited | −2.178 | 0.049 |
| CREM | Inhibited | −2.183 | 0.019 |
| USF2 | Inhibited | −2.206 | 0.0002 |
| CREB1 | Inhibited | −2.214 | 0.001 |
| TFEB | Inhibited | −2.216 | 0.006 |
| TNFSF11 | Inhibited | −2.232 | 0.006 |
| NR3C1 | Inhibited | −2.320 | 0.001 |
| SREBF2 | Inhibited | −2.401 | 0.010 |
| FOXA2 | Inhibited | −2.404 | 0.006 |
| TSC2 | Inhibited | −2.433 | 0.001 |
| NR1I2 | Inhibited | −2.483 | 0.001 |
| EIF4E | Inhibited | −2.530 | 0.032 |
| MAP2K1 | Inhibited | −2.608 | 0.035 |
| SREBF1 | Inhibited | −2.744 | 0.018 |
| TCR | Inhibited | −2.776 | 0.016 |
| PPARA | Inhibited | −2.813 | 0.0006 |
| HNF1A | Inhibited | −3.046 | 0.000002 |
| HNF4A | Inhibited | −3.834 | 2.08E-13 |