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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Pharm Res. 2014 Nov 19;32(5):1752–1763. doi: 10.1007/s11095-014-1573-2

Figure 1.

Figure 1

Illustration of the mathematical model and parameters used to describe heterogeneous Dox release kinetics from three different micelle formulations (HYD-M, ABZ-M, and GLY-M). Here, the hydrophilic PEG shell surrounds a core consisting of two populations of conjugated Dox corresponding to fast ( ) and slow ( ) hydrolysis governed by rate constants k1 and k2, respectively. After hydrolysis, unconjugated Dox may partition into the micelle ( ) or reside in the aqueous environment ( ), as governed by the partition coefficient Kp. In dynamic dialysis studies, Dox transport though the dialysis membrane is governed by the rate constant kd and unbound Dox concentration,.