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. Author manuscript; available in PMC: 2016 May 1.

Published in final edited form as: Pharm Res. 2014 Nov 19;32(5):1752–1763. doi: 10.1007/s11095-014-1573-2

Simulation of HYD-M (pH 5.0) release profile under non-sink conditions using rate constants in Table 1. The % Dox remaining after ultrafiltration () versus time along with the fit using the mechanistic model (gray line) are compared to a simulation with no partitioning of unconjugated Dox ( =0) into the micelle (gray dotted line). Based on the values in Table 1, the amount of unconjugated Dox that partitioned into the micelle was also simulated as a % of total Dox present in the solution (black line).

Inline graphic — Simulation of HYD-M (pH 5.0) release profile under non-sink conditions using rate constants in Table 1. The % Dox remaining after ultrafiltration () versus time along with the fit using the mechanistic model (gray line) are compared to a simulation with no partitioning of unconjugated Dox ( =0) into the micelle (gray dotted line). Based on the values in Table 1, the amount of unconjugated Dox that partitioned into the micelle was also simulated as a % of total Dox present in the solution (black line).