Table 1.
Drug release parameters determined through mathematical modelinga
| Micelle | pH | kf (hr−1) | ks × 102(hr−1) | kd (hr−1) | kp × 10−3 | Fkf |
|---|---|---|---|---|---|---|
| HYD-M | 7.4 | 0.24 ± 0.1 | 0.55 ± 0.1 | 0.81 ± 0.03 | 2.5 ± 0.6 | 0.38 ± 0.06 |
| ABZ-M | 7.4 | 0.27 ± 0.2 | 0.36 ± 0.1 | 0.79 ± 0.03 | 1.1 ± 0.8 | 0.34 ± 0.06 |
| GLY-M | 7.4 | 0.30 ± 0.1 | 0.46 ± 0.1 | 0.80 ± 0.03 | 2.2 ± 1 | 0.25 ± 0.04 |
| HYD-M | 5.0 | 0.29 ± 0.05 | 0.45 ± 0.1 | 0.80 ± 0.03 | 0.62 ± 0.2 | 0.68 ± 0.03 |
| ABZ-M | 5.0 | ≥ 1.15b | 0.59 ± 0.2 | 0.78 ± 0.03 | 0 | 0.36 ± 0.05 |
| GLY-M | 5.0 | 0.64 ± 0.5 | 0.82 ± 0.1 | 0.77 ± 0.02 | 0 | 0.20 ± 0.05 |
a
Data reported as fitted value ± 95% confidence intervals;
b
Value used for generation of statistics as release of fast phase was rate-limited by Dox transport through the dialysis membrane.