Table 1.

Exclusion criteria for COGS-1 and COGS-2.

		COGS-1		COGS-2
Exclusion criterion	All participants	Proband	HCS	Patient	HCS
Does not meet family inclusion criteria (see text)	X
Does not meet diagnostic criteria for SZ		X
Does not meet diagnostic criteria for SZ or schizoaffective disorder, depressed type		X		X
Adopted or family history unknown	X				X
Outside study age range of 18-65	X			X	X
Unable to understand consent due to language or competency	X			X	X
Physically unable to participate in testing of at least one endophenotype	X
Physically unable to participate in testing of at least two endophenotypes				X	X
Previous endophenotype testing in the last 1 mo	X			X	X
Previous neuropsychological testing in the last 3 mo	X			X	X
Positive illicit drug or alcohol screen at the time of testing		X	X	X	X
Severe systemic illness that interferes with ability to be endophenotyped	X			X	X
Parents not living (unless sibship is large) or unavailable for genotyping		X
Both parents diagnosed with SZ		X
Siblings unavailable for endophenotyping and genotyping		X
All siblings diagnosed with SZ		X
Electroconvulsive treatment in the last 6 mo		X	x	x	X
Alcohol or substance abuse in the past 1 mo		X	x	x	X
Alcohol or substance dependence not in remission for 6 mo		X	x	x	X
Significant head injury (loss of consciousness > 15 min and/or neurological sequelae)		X	x	x	X
Neurological illness (e.g., seizures, stroke, Parkinson disease)		X	x	X	X
Less than one 1 month psychiatrically stable		X	x
Estimated premorbid IQ < 70 per Wide Range Achievement Test-Third Edition		X	x	X	X
History of psychosis in themselves or a family member (1st or 2nd degree)			x
History of psychosis in themselves or a family member (1st degree)					X
Current Axis I mood disorder					X
Cluster A personality disorder			X		X
Current treatment with antipsychotic agents			X		X
Current treatment with any psychoactive medication					X
Participated in COGS-1 testing				X	X
First-degree relative who has already participated in this study				X	X