Table 3.

Putative moderating factors in analyses of COGS endophenotypes.

Factor	Example of putative moderating impact	Reference
Test site	COGS-1 site differences in CVLT performance	Stone et al. (2011)
Age	Significant reduction in MMN amplitude with increasing age	Kiang etal. (2009)
Sex	Superior immediate recall in women vs. men on CVLT	Ragland et al. (2000)
Antipsychotic (AP) use	“Normalized” PPI with 2nd generation AP use in COGS-2 SZ patients	Swerdlow et al. (2014)
Smoking status	Nicotine reduces AS errors in SZ patients	Rycroft et al. (2006)
Parental education	Significantly greater CNB performance with higher levels of parental education	Gur et al. (2001a)