Table 1. Patient Characteristics.
| Characteristics | TCD (N=52) | Unmodified (N=115) | p-value | ||
|---|---|---|---|---|---|
| Followup - survivors (months)* | 38.9 (20.5-97.4) | 47.9 (6.0,126.1) | - | ||
|
| |||||
| Age (years)* | 40.4 (18.0-67.2) | 34.0 (18.0,64.0) | 0.176 | ||
|
| |||||
| >50 Years | 13 (25.0) | 18 (15.7) | 0.221 | ||
|
| |||||
| Sex = Female | 18 (34.6) | 48 (41.7) | 0.483 | ||
|
| |||||
| Time to CR1 (days)* | 38.5 (7,180) | 30 (14,210) | 0.047 | ||
|
| |||||
| Time from CR1 (days) to HCT* (CR1 patients only) | 109.0 (15.0,288.0) | 101.0 (16.0,570.0) | 0.787 | ||
|
| |||||
| Immunophenotype | 0.099 | ||||
| T-Cell | |||||
| WBC ≤ 50,000 | 3 (5.8) | 10 (8.7) | |||
| WBC > 50,000 | 3 (5.8) | 1 (0.9) | |||
| missing | 1 (1.9) | 1 (0.9) | |||
| B-Cell | 0.102 | ||||
| WBC ≤ 30,000 | 25 (48.1) | 53 (46.1) | |||
| WBC > 30,000 | 6 (11.5) | 32 (27.8) | |||
| missing | 4 (7.7) | 18 (15.7) | |||
| Other | 9 (17.3) | - | |||
| missing | 1 (1.9) | - | |||
|
| |||||
| Cytogenetic Risk | 0.747 | ||||
| Good | 1 (2.0) | 5 (4.9) | |||
| Standard | 29 (58.0) | 61 (59.8) | |||
| Poor | 20 (40.0) | 36 (35.3) | |||
| missing | 2 | 13 | |||
|
| |||||
| Donor Type | <0.001 | ||||
| Matched Related | 21 (40.4) | 72 (62.6) | |||
| Matched Unrelated | 15 (28.8) | 42 (36.5) | |||
| Mismatch | 16 (30.8) | 1 (0.9) | |||
|
| |||||
| Stem Cell Source | 0.003 | ||||
| Bone Marrow | 6 (11.5) | 40 (34.8) | |||
| Peripheral Blood | 46 (88.5) | 75 (65.2) | |||
|
| |||||
| TKI1 | 0.849 | ||||
| yes | 5 (22.7) | 13 (28.3) | |||
| no | 17 (77.3) | 33 (71.7) | |||
|
| |||||
| CR Status | |||||
| 1st | 36 (69.2) | 60 (52.2) | 0.058 | ||
| 2nd | 16 (30.8) | 55 (47.8) | |||
|
| |||||
| ATG | < 0.001 | ||||
| yes | 39 (75.0) | 29 (25.2) | |||
| no | 13 (25.0) | 86 (74.8) | |||
|
| |||||
| TBI | < 0.001 | ||||
| yes | 47 (90.4) | 62 (53.9) | |||
| no | 5 (9.6) | 53 (46.1) | |||
*
Median(range)
1
Counts (percents) based on total po ssible individuals rec eiving TKI
Numeric variables tested via Wilcoxon Signed-Ranked Test
Categorical variables tested via Pearson's Chi-squared or Fisher's Exact Tests (excluding missing values) where appropriate.