. Author manuscript; available in PMC: 2016 May 1.

Published in final edited form as: Pharm Res. 2014 Nov 13;32(5):1663–1675. doi: 10.1007/s11095-014-1565-2

Table 3.

Effect of Ces1c expression on the cytotoxicity of phospho-NSAIDs. The Ces1c/Control ratios represent the fold changes in IC50 in 293T-Ces1c cells as compared to 293T-Control cells.

	IC₅₀, µM		Ces1c/ Control ratio
	293T- Control	293T- Ces1c	Ces1c/ Control ratio
	Phospho-aspirin (MDC-46)	953 ± 34	787 ± 26	0.8
Phospho-aspirin (MDC-22)	507 ± 14	755 ± 197	1.5
Phospho-ibuprofen	62 ± 6	775 ± 96	13
Phospho-indomethacin	45 ± 1	101 ± 3	2.3
Phospho-tyrosol-indomethacin	59 ± 3	297 ± 27	5.0
Phospho-naproxen	69 ± 5	1280 ± 370	19
Phospho-sulindac	28 ± 2	112 ± 7	4.0
Phospho-valproic acid	41 ± 2	105 ± 16	2.6