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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Pharm Res. 2014 Nov 13;32(5):1663–1675. doi: 10.1007/s11095-014-1565-2

Table 5.

Pharmacokinetic parameters for P-S.

Pharmacokinetic
parameters		 P-S
(300 mg/kg, i.p.)		 PLA-PEG P-S
(50 mg/kg, i.v.)		 Pluronic P123 P-S
(40mg/kg, i.v.)
Wild type Ces1c −/− Wild type Ces1c −/− Wild type Ces1c −/−
C0, µM - - 178 173 33.8 46.0
Cmax, µM 40.4 76.8 169 177 19.0 32.1
Tmax, h 0.55 1.25 0.08 0.08 0.08 0.08
AUC0–24h, µM*h 155 261 136 284 4.69 11.3
t1/2, h 2.24 0.87 0.53 1.14 0.09 0.17
CL, mg/µM/h 0.04 0.02 0.007 0.004 0.17 0.07
Vss, mg/µM - - 0.006 0.006 0.02 0.02