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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Annu Rev Phys Chem. 2015 Jan 12;66:357–377. doi: 10.1146/annurev-physchem-040214-121802

Figure 6.

Figure 6

(a) The frequency-field map for the C=O stretching vibration of acetophenone, determined via IR measurements in different solvents and MD simulations. (b) Cartoon representation of the binding of the S-peptide to the S-protein of Ribonuclease S, which brings the site-specific C=O probe (red) to an environment with a smaller electrostatic field. Figure adapted with permission from Fried et al. (125).