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. Author manuscript; available in PMC: 2016 Mar 31.
Published in final edited form as: Circulation. 2015 Feb 20;131(13):1202–1213. doi: 10.1161/CIRCULATIONAHA.114.012669

Figure 2.

Figure 2

Adamts7 deficiency reduces atherosclerosis in the Ldlr KO hyperlipidemic mouse model. A) Representative oil-red O stained aortas from male Adamts7+/+/Ldlr−/− and Adamts7−/−;Ldlr−/− mice after 16-weeks of western diet feeding. B) Quantification of atherosclerosis in the aortas of these mice, both male (N=21, 31) and female (N=28, 34). Lesion area is represented as percent area of the entire aorta. C) Representative H/E stained aortic roots from male Adamts7+/+/Ldlr−/− and Adamts7−/−;Ldlr−/− mice. D) Quantification of aortic root lesion area between the two animal groups in both sexes. Lesion area was calculated in 5 serial sections through the aortic root, and an average value was obtained for each mouse.