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. Author manuscript; available in PMC: 2016 Mar 31.
Published in final edited form as: Circulation. 2015 Feb 20;131(13):1202–1213. doi: 10.1161/CIRCULATIONAHA.114.012669

Figure 6.

Figure 6

Adamts7 vascular expression is transiently induced in response to mechanical and hyperlipidemic stress in mouse models. (A-C) Femoral arteries were X-gal stained overnight at the indicated timepoints (N=4/timepoint) following endothelial denudation by wire injury. Representative sections from the resultant stained injured vessels are shown revealing positive X-gal staining in the media and adventitia of vessels 7 days post-injury. Panel B includes increased magnification of the boxed region from the 7-day injury. (D-F) X-gal staining of atherosclerotic BCA lesions from Adamts7−/−;Apoe−/− mice fed western diet for 1, 4, and 10 weeks (N=3/timepoint). Panel E includes higher magnification of the boxed region from the 4-week lesion. (G) X-gal staining in primary VSMCs with and without 24-hour treatment with 25ng/ml TNFα.