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IL-10 signaling pathways in normal and abnormal conditions. Binding of IL-10 to its specific receptor complex (IL-10R1 and IL-10R2) leads to activation of several signaling pathways, including well-established Jak/STAT pathway, PI3K/Akt- and P38/MAPK-mediated pathways, as well as CO-mediated pathway. Through its signal transduction, IL-10 plays a role in anti-inflammation, vascular protection and inhibition of ER stress and autophagy.
