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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Antibiot (Tokyo). 2014 Oct 1;68(4):271–278. doi: 10.1038/ja.2014.133

Figure 3.

Figure 3

Bactericidal activity of UT-01320 against non-replicating Mtb evaluated in Wayne and nutrient deficient models.

M. tuberculosis entered dormant states were cultured with the inhibitors. After 96h under anaerobic (Wayne model) or nutrient deficient conditions, 10-, 100-, 1,000- and 10,000-fold serial dilutions from each culture tube was sampled, and 20μL from each dilution was plated on 7H10 agar plates supplemented with OADC enrichment. Plates were incubated under aerobic conditions for 15 days in a static incubator at 37 °C and colonies were counted. CFU counted for each plate is shown relative to control (100). UT-01320 (3) killed M. tuberculosis at the MICLORA concentrations in both assays. A: Wayne model.; B: a nutrient deficient model.