Table 2.
Fractional inhibitory concentration of a combination of two inhibitor molecules.a
| Combination of A and B | MICA (μg/mL) MICB (μg/mL)b |
MIC (μg/mL) CA and CBc |
ΣFICd |
|---|---|---|---|
| A: SQ 641 (2) | 1.56 1.50 |
0.10 0.08 |
0.12 |
| B: UT-01320 (3) | |||
| A: SQ 641 (2) | 1.56 1.50 |
0.10 0.16 |
0.17 |
| B: UT-01320 (3) | |||
| A: SQ 641 (2) | 1.56 1.50 |
0.10 0.32 |
0.28 |
| B: UT-01320 (3) | |||
| A: SQ 641 (2) | 1.56 1.50 |
0.10 0.645 |
0.49 |
| B: UT-01320 (3) | |||
| A: SQ 641 (2) | 1.56 1.50 |
0.10 1.29 |
0.92 |
| B: UT-01320 (3) | |||
| A: Capuramycin (1) | 12.5 1.50 |
1.563 0.08 |
0.18 |
| B: UT-01320 (3) | |||
| A: Capuramycin (1) | 12.5 1.50 |
1.563 0.16 |
0.23 |
| B: UT-01320 (3) | |||
| A: Capuramycin (1) | 12.5 1.50 |
0.78 0.32 |
0.28 |
| B: UT-01320 (3) | |||
| A: Capuramycin (1) | 12.5 1.50 |
0.78 0.645 |
0.49 |
| B: UT-01320 (3) | |||
| A: Capuramycin (1) | 12.5 1.50 |
0.78 1.29 |
0.92 |
| B: UT-01320 (3) |
a
ΣFIC index for the wells at growth–no growth interface.
b
MICA and MICB are the MIC value of molecule A or B against Mtb (see Table 1).
c
CA and CB are concentrations of A and B.
d
ΣFIC is the sum of fractional inhibitory concentration calculated by the equation ΣFIC = FICA + FICB = CA/MICA + CB/MICB.