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Summary of the immunohistochemical studies according to the tumor component
| Marker | Squamous cell carcinoma | Neuroendocrine carcinoma |
|---|---|---|
| Cytokeratin AE1/AE3 | ++ | +++ |
| Cytokeratin 5/6 | +++ | − |
| p63 | +++ | − |
| Neuron specific enolase | − | +++ |
| Synaptophysin | − | ++ |
| Chromogranin | − | +++ |
| CD56 | − | ++ |
| p16 | − | − |
| p53 | − | +++ |
