Table 1.

Mean Standard Deviation and Test of Significance of mean values between patients and controls.

Variables	Patient saliva	Controls saliva	Controls serum	p-value
	Mean ± S.D	Mean ± S.D	Mean ± S.D	<0.001
0 h Concentration μ g/ml	2.4 ± 1.4	0.4 ± 0.2	0.5 ± 0.2	<0.001
4 h Concentration μg/ml	19.7 ± 1.7	5.9 ± 0.9	7.9 ± 1.2	<0.001
16 h Concentration μg/ml	11.7 ± 2.8	0.9 ± 0.2	1.2 ± 0.3	<0.001
Caffeine Clearance Ml/min/kg	0.5 ± 0.2	1.6 ± 0.2	1.6 ± 0.3	<0.001