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Examples of patients classified as having a small (a grade 1), medium (b grade 3) and large (c grade 5) tumour burden. The patient with a small tumour burden (a) has a single tumour located in the abdomen, the patient with a medium tumour burden (b) has multiple tumours in the abdomen, and the patient with a large tumour burden (c) has multiple tumours in the liver involving around 50 % of the parenchyma
