Table 2. Multivariable analysis of clinical and laboratory factors at diagnosis associated with OS.

Variables at diagnosis	Univariate analysis		Multivariate analysis
	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value
Age ⩾70	2.32 (1.95–2.76)	<0.001	2.48 (1.77–3.44)	<0.001
ISS 3	2.12 (1.75–2.56)	<0.001	1.35 (0.90–1.99)	0.139
LDH>192 IU/dL	1.43 (1.16–1.76)	<0.001	1.33 (0.94–1.88)	0.106
Novel agent induction	0.47 (0.40–0.56)	<0.001	0.63 (0.46–0.89)	0.008
High-risk FISH	1.89 (1.43–2.48)	<0.001	2.00 (1.41–2.80)	<0.001
CrCl<40 ml/min (RI at diagnosis)	1.90 (1.54–2.32)	<0.001	1.21 (0.72–2.12)	0.477

Abbreviations: CI, confidence interval; CrCl, creatinine clearance; FISH, fluorescent in situ hybridization; ISS, international staging system; LDH, lactate dehydrogenase; OS, overall survival; RI, renal impairment. Italics signifies statistically significant (P<0.05 in the Univariate analysis and P<0.008 in the Multivariate analysis).