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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Curr Opin Chem Biol. 2014 Dec 10;24:97–103. doi: 10.1016/j.cbpa.2014.10.024

Figure 3.

Figure 3

Chemical structures of small molecules that inhibit Dicer and Drosha processing of precursor miRNAs and the corresponding miRNA secondary structures. (A) 6 and 7 inhibit Dicer processing. Inhibition of miR-21 processing by streptomycin up-regulates PDCD4, which induces apoptosis. Inhibition of miR-372 and -373 processing by 7 causes up-regulation of LATS2 inducing cytostatic effects. (B) 8 and 9 inhibit Drosha processing of miR-96 and miR-10b, respectively. Inhibition of miR-96 processing up-regulates FOXO1 thereby inducing apoptosis. Inhibition of miR-10b processing induces up-regulation of HOXD10, which can inhibit cell migration and metastasis. Drosha and Dicer processing sites are indicated with arrows.