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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Curr Opin Chem Biol. 2014 Dec 10;24:97–103. doi: 10.1016/j.cbpa.2014.10.024

Figure 4.

Figure 4

Compound 8 selectively inhibits miR-96. (A) Fitness plot for 8, which indicates optimal and sub-optimal RNA targets. Selectivity window based on fitness score predicts if a miRNA hairpin precursor can be targeted by 8. (B) Profiling the change in expression of 149 miRNAs upon treatment with 8 (diamond) and an antagomir targeting miR-96 (triangle). Only miR-96 is affected (≥2.5 fold) upon treatment with 8. However, treatment with an antagomir affects expression of 12 miRNAs (≥2.5-fold).