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. 2015 Mar 11;6:6495. doi: 10.1038/ncomms7495

Figure 10. Schematic overview of the phenotype observed following Napepld deletion in adipocytes.

Figure 10

When NAPE-PLD is present and functional, adipose tissue homeostasis is maintained and this participates in a normal crosstalk between adipose tissue and gut microbiota. Moreover the presence of NAPE-PLD participates in normal glucose homeostasis and lipid flows. When NAPE-PLD is absent, adipose tissue metabolism is deregulated, with an increase in inflammation, decrease in the browning capacity and excessive fat mass development. Napepld deletion also induces alterations in glucose homeostasis and alters normal lipid flows and lipid homeostasis in circulation and in adipose tissue. Altered adipose metabolism following Napepld deletion induces a dysbiosis of the gut microbiota, which in turn participates in the metabolic alterations observed in the adipose tissue.