Table 3.
Mental Stress Induced Bio-Psychological Reactivity and Platelet Aggregation (Post-stress – Resting)
| Variables | NLVR N=48 |
MSIMI N=117 |
Intermediate N=104 |
P-value* |
|---|---|---|---|---|
| Variables Summarized as Mean (SE) | ||||
| Cardiovascular Reactivity | ||||
| Δ Systolic blood pressure | 29.88(1.87) | 26.52(1.19) | 24.35(1.21) | .14 |
| Δ Diastolic blood pressure | 15.25(1.35) | 14.59(0.86) | 12.95(0.83) | .69 |
| Δ Heart rate | 10.94(1.31) | 9.28(0.84) | 8.57(0.78) | .29 |
| Δ Wall motion score index | −0.01(0.02) | 0.11(0.01) | −.003(.002) | <.001 |
| Δ Left ventricular ejection fraction | 4.65(0.63) | −2.54(0.42) | −0.93(0.24) | <.001 |
| Δ Platelet Aggregation (AUC) | ||||
| ADP 5 μM | −2.47(7.92) | 9.55(4.97) | −2.55(6.47) | .21 |
| Epinephrine, 10 μM | −6.40(7.61) | 12.84(4.84) | 11.04(7.74) | .037 |
| Collagen, 10 μM | −14.23(8.75) | 6.95(5.54) | 6.98(7.10) | .045 |
| Individual Agonist Composite Score | −0.27(0.14) | 0.10(0.09) | −0.01(0.12) | .030 |
| Serotonin+ ADP | −27.24(8.34) | 6.64(5.29) | −9.19(5.66) | <.001 |
| Serotonin+Epinephrine | −11.58(9.31) | 2.57(5.90) | 7.43(6.56) | .21 |
| Serotonin+Collagen | −45.10(9.90) | −31.36.(6.27) | −36.33(6.46) | .25 |
| Serotonin + Agonist Composite Score | −0.29(0.15) | 0.12(0.09) | 0.02(0.10) | .019 |
| Emotional Response | ||||
| Sadness | 7.90(2.67) | 7.61(1.68) | 11.21(2.01) | .93 |
| Tension | 28.22(3.12) | 23.10(1.97) | 27.78(2.49) | .17 |
| Frustration | 44.93(3.17) | 42.07(2.00) | 44.98(2.64) | .45 |
| Calm | −28.59(3.24) | −24.95(2.04) | −29.24(2.54) | .35 |
| In Control | −31.17(2.98) | −27.11(1.88) | −29.22(2.75) | .26 |
*
The P values reflect ANCOVAs comparing variables between MSIMI (N = 117) and NLVR (N = 48) groups controlling for age, sex, smoking status, BDI scores, resting LVEF, and appropriate resting cardiovascular index.