. Author manuscript; available in PMC: 2016 Mar 1.

Published in final edited form as: J Orthop Res. 2014 Nov 18;33(3):334–342. doi: 10.1002/jor.22761

Table 1.

Osteoclast numbers and mineral apposition rates in the distal femur following irradiation.

Treatment (Gy)	Time (weeks)	Sample Size	Number of Osteoclasts (#)				Mineral Apposition Rate (um/day)

			Trabecular	Periosteal	Endosteal	Distal 5mm	Periosteal Diaphysis	Endosteal Diaphysis	Periosteal Metaphysis	Endosteal Metaphysis	Average	Total
0 Gy	1	n = 12	15.5 ± 1.6	1.5 ± 0.3	0.5 ± 0.2	17.6 ± 1.7	0.63 ± 0.26	0.98 ± 0.42	0.01 ± 0.02	2.79 ± 0.83	1.10 ± 0.23	8.80 ± 1.85
	2	n = 11	17.4 ± 1.7	1.1 ± 0.3	0.0 ± 0.0	18.5 ± 2.0	0.27 ± 0.29	0.98 ± 0.53	0.00 ± 0.00	2.58 ± 0.68	0.96 ± 0.21	7.65 ± 1.66
	4	n = 12	16.2 ± 1.8	1.4 ± 0.4	0.4 ± 0.2	18.0 ± 1.7	0.30 ± 0.25	0.71 ± 0.26	0.00 ± 0.00	2.35 ± 0.89	0.84 ± 0.24	6.73 ± 1.93
	8	n = 12	18.6 ± 2.2	0.9 ± 0.2	0.5 ± 0.3	20.0 ± 2.4	0.43 ± 0.29	0.44 ± 0.33	0.00 ± 0.00	1.39 ± 0.33	0.57 ± 0.10	4.54 ± 0.82
	12	n = 11	17.8 ± 2.2	1.0 ± 0.2	1.3 ± 0.5	20.1 ± 2.4	0.51 ± 0.16	0.35 ± 0.25	0.00 ± 0.00	1.09 ± 0.23	0.49 ± 0.07	3.89 ± 0.56
	26	n = 12	21.5 ± 1.4	0.8 ± 0.2	1.9 ± 0.3	24.3 ± 1.5	0.38 ± 0.27	0.22 ± 0.16	0.02 ± 0.07	0.79 ± 0.17	0.35 ± 0.07	2.83 ± 0.58

5 Gy	1	n = 6	^*28.7 ± 5.4	3.3 ± 0.9	1.3 ± 1.0	^*33.3 ± 6.5	0.56 ± 0.17	1.22 ± 0.59	0.02 ± 0.04	3.51 ± 0.28	1.25 ± 0.31	9.98 ± 2.46
	2	n = 6	^*50.3 ± 3.1	^*4.0 ± 1.0	0.8 ± 0.3	^*55.1 ± 3.2	0.20 ± 0.49	^*2.06 ± 0.75	0.00 ± 0.00	3.54 ± 0.98	^*1.45 ± 0.32	11.61 ± 2.52
	4	n = 6	10.0 ± 2.2	0.9 ± 0.2	0.8 ± 0.2	11.8 ± 2.3	0.09 ± 0.15	0.85 ± 0.24	0.00 ± 0.00	1.82 ± 0.90	0.69 ± 0.24	5.53 ± 1.95
	8	n = 6	^*5.0 ± 1.0	0.4 ± 0.2	0.3 ± 0.2	^*5.8 ± 1.0	0.31 ± 0.31	0.67 ± 0.35	0.00 ± 0.00	1.19 ± 0.20	0.54 ± 0.08	4.35 ± 0.63
	12	n = 6	^*6.3 ± 0.6	0.3 ± 0.1	0.3 ± 0.2	^*6.8 ± 0.7	0.38 ± 0.15	0.25 ± 0.07	0.00 ± 0.00	1.06 ± 0.16	0.42 ± 0.06	3.38 ± 0.46
	26	n = 6	^*5.3 ± 0.6	0.4 ± 0.2	1.7 ± 0.4	^*7.4 ± 0.7	0.25 ± 0.31	0.48 ± 0.12	0.02 ± 0.04	0.79 ± 0.23	0.39 ± 0.09	3.08 ± 0.72

4x5 Gy	1	n = 6	^#11.3 ± 1.4	1.9 ± 0.5	0.3 ± 0.2	^#13.5 ± 1.8	0.45 ± 0.17	^*1.90 ± 0.40	0.00 ± 0.00	3.78 ± 0.86	^*1.53 ± 0.22	^*12.25 ± 1.80
	2	n = 5	^*44.0 ± 1.8	^*3.7 ± 0.8	1.7 ± 0.6	^*49.4 ± 2.2	0.24 ± 0.31	1.57 ± 0.34	0.00 ± 0.00	2.86 ± 0.81	1.07 ± 0.24	8.56 ± 1.90
	4	n = 6	7.2 ± 0.8	1.0 ± 0.3	0.5 ± 0.2	8.7 ± 0.8	0.28 ± 0.23	0.76 ± 0.26	0.00 ± 0.00	2.45 ± 0.39	0.87 ± 0.12	6.98 ± 0.93
	8	n = 6	^*5.8 ± 1.0	0.3 ± 0.2	0.6 ± 0.2	^*6.7 ± 1.0	0.08 ± 0.14	^*^#1.99 ± 0.52	0.00 ± 0.00	^*^#2.58 ± 0.46	^*^#1.16 ± 0.15	^*^#9.30 ± 1.23
	12	n = 6	^*3.8 ± 1.0	0.4 ± 0.3	1.3 ± 0.3	^*5.4 ± 1.3	0.11 ± 0.18	0.68 ± 0.06	0.02 ± 0.05	0.71 ± 0.28	0.38 ± 0.10	3.03 ± 0.82
	26	n = 6	^*4.3 ± 0.9	0.1 ± 0.1	1.4 ± 0.5	^*5.8 ± 1.1	0.18 ± 0.14	0.45 ± 0.16	0.00 ± 0.00	0.54 ± 0.18	0.29 ± 0.06	2.33 ± 0.50

Osteoclast numbers and mineral apposition rates (MARs, average ± SEM;

p<0.05 vs. 0 Gy;

p<0.05 vs. 5 Gy).