Table 1.
Overrepresented Gene ontology (GO) terms for up- (↑) and down- regulated (↓) genes in infected liver
| Major Function | Transcription | p-value * |
|---|---|---|
| Oxidoreductase activity | ||
| cholesterol 7-alpha-monooxygenase activity (GO:0008123) | ↓ | 0.0017 |
| flavin-containing monooxygenase activity (GO:0004499) | ↓ | 0.0086 |
| leukotriene-B4 20-monooxygenase activity (GO:0050051) | ↓ | 0.0069 |
| arachidonic acid 11 12-epoxygenase activity (GO:0008405) | ↓ | 0.0017 |
| arachidonic acid 14 15-epoxygenase activity (GO:0008404) | ↓ | 0.0017 |
| alkane 1-monooxygenase activity (GO:0018685) | ↓ | 0.0086 |
| linoleic acid epoxygenase activity (GO:0071614) | ↓ | 0.0017 |
| Immune system | ||
| neutrophil aggregation (GO:0070488) | ↑ | 0.0007 |
| neutrophil chemotaxis (GO:0030593) | ↑ | 0.0004 |
| regulation of T-helper 2 cell differentiation (GO:0045628) | ↑ | 0.0015 |
| regulation of B cell activation (GO:0050864) | ↑ | 0.0007 |
| negative regulation of B cell apoptosis (GO:0002903) | ↑ | 0.0015 |
| cellular response to type I interferon (GO:0071357) | ↓ | 0.0017 |
| positive regulation of interferon-alpha production (GO:0032727) | ↓ | 0.0001 |
| positive regulation of interferon-beta production (GO:0032728) | ↓ | 0.0006 |
| regulation of type III interferon production (GO:0034344) | ↓ | 0.00001 |
| Extracellular matrix | ||
| collagen type I (GO:0005584) | ↑ | 0.0007 |
| proteinaceous extracellular matrix (GO:0005578) | ↑ | 0.0002 |
| extracellular matrix (GO:0031012) | ↑ | 0.0007 |
*p-value < 0.05.
Analysis revealed GO terms related with oxidoreductase (‘molecular function’), immune system (‘biological processes’) and extra cellular matrix (‘cellular component’).
Full list of GO analyses can be seen in Additional file 3.