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. 2015 Mar 25;15:21. doi: 10.1186/s12911-015-0140-z

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© Tanskanen et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The overall operation of PRE2DUP. Data is first preprocessed, and then drug use periods are calculated. New parameters are calculated iteratively, to improve the results. Green arrows show the work-flow around the core process. Red numbers link to particular sections in the text.